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Delta-9-tetrahydrocannabinol: localization in body fat
Summary
Tetrahydrocannabinol (THC) distributes to fat tissue, persisting for weeks after a single dose. Repeated THC injections lead to accumulation in both fat and brain tissues.
Area of Science:
- Pharmacology
- Toxicology
- Neuroscience
Background:
- Tetrahydrocannabinol (THC) is a primary psychoactive component of cannabis.
- Understanding THC distribution and persistence in the body is crucial for assessing its effects and duration of action.
Purpose of the Study:
- To investigate the tissue distribution and persistence of Delta(9)-Tetrahydrocannabinol (Delta(9)THC) and its metabolites in rats.
- To determine the impact of single versus repeated subcutaneous administration of Delta(9)THC on tissue concentrations.
Main Methods:
- Rats were administered daily subcutaneous injections of [(14)C]Delta(9)-Tetrahydrocannabinol (Delta(9)THC) for 1 to 26 days.
- Concentrations of Delta(9)THC and its key metabolites (11-hydroxytetrahydrocannabinol, 8,11-dihydroxytetrahydrocannabinol) were quantified in various tissues.
- Radioactive labeling [(14)C] was used to track the compound and its metabolites.
Main Results:
- Following a single injection, Delta(9)THC concentrations were highest in adipose tissue, approximately ten times greater than in other examined tissues.
- Delta(9)THC persisted in adipose tissue for up to 2 weeks after a single dose.
- Repeated daily injections of Delta(9)THC resulted in significant accumulation of both the parent compound and its metabolites in adipose tissue and brain tissue.
Conclusions:
- Adipose tissue serves as a significant reservoir for Delta(9)THC, leading to prolonged retention.
- Repeated exposure to Delta(9)THC promotes its accumulation in both peripheral (fat) and central (brain) tissues.
- These findings highlight the importance of considering adipose tissue in pharmacokinetic models of THC and its potential for long-term effects with chronic use.
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