Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioavailability study of gitoxin in a solid dosage form.

C Hupin, J M de Suray, J Versluys

    International Journal of Clinical Pharmacology and Biopharmacy
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Renal transplantation outcomes in obese patients: a French cohort-based study.

    BMC nephrology·2021
    Same author

    The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research.

    BMC nephrology·2019
    Same author

    Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report.

    Clinical and translational allergy·2017
    Same author

    Non-allergic rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology.

    Allergy·2017
    Same author

    Molecular identification of iridoviruses infecting various sturgeon species in Europe.

    Journal of fish diseases·2016
    Same author

    Chronic inflammatory airway diseases: the central role of the epithelium revisited.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016

    Gitoxin, a cardiotonic drug, shows poor oral absorption. Developing a solid tablet formulation with sodium escinate may improve its bioavailability for therapeutic use.

    Area of Science:

    • Pharmacology
    • Pharmaceutical Technology

    Background:

    • Gitoxin, a digitalis glycoside, possesses known cardiotonic activity.
    • Therapeutic application of gitoxin has been limited due to poor oral bioavailability.

    Purpose of the Study:

    • To develop a solid dosage form for gitoxin.
    • To enhance the oral bioavailability of gitoxin.

    Main Methods:

    • Investigated the physical association of gitoxin with sodium escinate.
    • Developed a solid dosage form (tablets).

    Main Results:

    • Recent studies indicate 100% bioavailability of gitoxin in hydroalcoholic solutions.
    • This study focuses on creating a solid formulation for improved gitoxin delivery.

    Related Experiment Videos

    Conclusions:

    • A solid dosage form combining gitoxin and sodium escinate is under development.
    • This approach aims to overcome the oral absorption limitations of gitoxin.