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Related Experiment Videos

Systemic corticosteroids in alopecia totalis.

W P Unger

    Canadian Medical Association Journal
    |January 20, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Short courses of systemic corticosteroids may effectively treat alopecia areata. Discontinuing therapy doesn't always cause rapid hair loss recurrence, and resistant areas may respond to topical treatments.

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    Area of Science:

    • Dermatology
    • Trichology

    Background:

    • Alopecia totalis is a severe form of hair loss.
    • Treatment often involves prolonged systemic corticosteroids.

    Purpose of the Study:

    • To present two cases of alopecia totalis.
    • To observe the course and treatment of the disorder.
    • To evaluate the efficacy of shorter corticosteroid courses and alternative therapies.

    Main Methods:

    • Case study presentation.
    • Observation of disease course and treatment response.
    • Administration of systemic corticosteroids.
    • Application of topical and intralesional therapies.

    Main Results:

    • Extensive alopecia areata may be triggered by short-lived stimuli, suggesting shorter systemic corticosteroid courses may suffice.

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  • Discontinuation of systemic therapy did not invariably lead to rapid recurrence of alopecia totalis.
  • Alopecia partialis following therapy cessation could be managed conservatively.
  • Areas resistant to 30 mg. prednisone daily responded to topical/intralesional treatments during prednisone dose reduction.

    • Conclusions:

    • Shorter systemic corticosteroid courses might be effective for alopecia areata.
    • Conservative management is possible for alopecia partialis after systemic therapy.
    • Combined topical/intralesional therapies can be beneficial for resistant alopecia totalis.