Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clofibrate-induced antidiuresis.

A M Moses, J Howanitz, M van Gemert

    The Journal of Clinical Investigation
    |March 1, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bone quality assessment in type 2 diabetes mellitus.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2014
    Same author

    Paget's disease of bone: the skeletal distribution, complications and quality of life as perceived by patients.

    Bone·2010
    Same author

    Phylogenetic motif detection by expectation-maximization on evolutionary mixtures.

    Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing·2004
    Same author

    In memoriam: David H. P. Streeten.

    The Journal of clinical endocrinology and metabolism·2001
    Same author

    Single infusion of zoledronate in Paget's disease of bone: a placebo-controlled, dose-ranging study.

    Bone·1999
    Same author

    Reproductive dysfunction in women with Albright's hereditary osteodystrophy.

    The Journal of clinical endocrinology and metabolism·1998
    Same journal

    Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

    The Journal of clinical investigation·2026
    Same journal

    Extracellular matrix reprogramming by the YAP/TAZ- TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models.

    The Journal of clinical investigation·2026
    Same journal

    Tumor cell-derived extracellular vesicles foster the immunosuppressive landscape of pancreatic cancer.

    The Journal of clinical investigation·2026
    Same journal

    Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award.

    The Journal of clinical investigation·2026
    Same journal

    Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

    The Journal of clinical investigation·2026
    Same journal

    SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.

    The Journal of clinical investigation·2026
    See all related articles

    Clofibrate demonstrates an antidiuretic hormone (ADH)-like effect by stimulating endogenous ADH release. This action was confirmed in patients with ADH deficiency and in rat models, indicating clofibrate enhances water reabsorption.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Pharmacology

    Background:

    • Antidiuretic hormone (ADH) regulates water balance.
    • The mechanism of clofibrate's antidiuretic effect was previously unclear.

    Purpose of the Study:

    • To elucidate the mechanism behind clofibrate's antidiuretic action.
    • To investigate the role of endogenous antidiuretic hormone (ADH) in clofibrate's effects.

    Main Methods:

    • Studied normal subjects and patients with ADH deficiency.
    • Administered clofibrate during standardized dehydration and water loading tests.
    • Utilized Brattleboro rats with and without ADH for further investigation.

    Main Results:

    • Patients with ADH deficiency showed clofibrate-induced antidiuresis similar to ADH.

    Related Experiment Videos

  • Clofibrate's effect was partially inhibited by ethanol and water loading.
  • Clofibrate failed to induce antidiuresis in rats lacking ADH but not in normal rats.

    • Conclusions:

    • Clofibrate exhibits a significant ADH-like action.
    • This effect appears to be mediated by the release of endogenous ADH.
    • Clofibrate influences water excretion by modulating ADH activity.