Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyaluronates: relation between molecular conformations.

E D Atkins, J K Sheehan

    Science (New York, N.Y.)
    |February 9, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.

    Mucosal immunology·2012
    Same author

    Investigation of glass-ionomer cements using differential scanning calorimetry.

    Journal of materials science. Materials in medicine·2004
    Same author

    Interaction between mycobacteria and mucus on a human respiratory tissue organ culture model with an air interface.

    Experimental lung research·2004
    Same author

    Hyaluronan: polysaccharide chaos to protein organisation.

    Current opinion in structural biology·2002
    Same author

    Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin.

    Glycobiology·2001
    Same author

    A comparison of post-operative morbidity following outpatient dental care under general anaesthesia in paediatric patients with and without disabilities.

    International journal of paediatric dentistry·2001
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    Hyaluronic acid salts exhibit remarkable conformational versatility, forming double-strand helices that convert to single-strand structures. This study reveals the interrelation of various hyaluronate conformations under different conditions.

    Area of Science:

    • Biopolymer science
    • Structural biology
    • Materials science

    Background:

    • Hyaluronic acid is a versatile biopolymer with known single-strand helical structures.
    • Understanding its conformational flexibility is crucial for various applications.

    Purpose of the Study:

    • To investigate the conformational versatility of hyaluronic acid salts.
    • To explore the existence of double-strand helical conformations in hyaluronic acid.
    • To elucidate the interrelation between different hyaluronate conformations.

    Main Methods:

    • X-ray diffraction was employed to analyze molecular conformations.
    • Conformational changes were monitored under varying relative humidity, temperature, and applied tension.

    Main Results:

    Related Experiment Videos

    • Both potassium and sodium hyaluronate salts were found to exist in a double-strand helical conformation.
    • These double-strand helices were observed to convert into the known single-strand helical structures.
    • A comprehensive scheme illustrating the interrelation of multiple hyaluronate conformations was developed.

    Conclusions:

    • Hyaluronic acid demonstrates significant conformational versatility, capable of adopting both double- and single-strand helical forms.
    • Environmental factors like humidity, temperature, and tension play a critical role in dictating hyaluronate conformation.
    • The findings provide a framework for understanding and potentially controlling hyaluronic acid's structural states.