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Related Experiment Videos

Plasma acetate turnover and oxidation.

C L Skutches, C P Holroyde, R N Myers

    The Journal of Clinical Investigation
    |September 1, 1979
    PubMed
    Summary
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    Younger individuals exhibit higher plasma acetate turnover and oxidation rates compared to older adults. Acetate metabolism in cancer patients mirrors that of age-matched healthy individuals, with the gut contributing to acetate production.

    Area of Science:

    • Metabolic studies
    • Human physiology
    • Biochemistry

    Background:

    • Acetate, a short-chain fatty acid, plays a role in human metabolism.
    • Understanding acetate turnover and oxidation is crucial for metabolic health insights.

    Purpose of the Study:

    • To investigate plasma acetate turnover and oxidation rates in healthy individuals across different age groups.
    • To compare acetate metabolism in cancer patients with age-matched healthy controls.
    • To determine tissue-specific acetate uptake and production in humans.

    Main Methods:

    • Constant infusion of trace [1-14C]acetate for 6 hours in 11 healthy subjects.
    • Measurement of plasma acetate concentration, turnover rate, and oxidation to CO2.
    • Assessment of arterial-venous acetate concentration differences across tissues.

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    Main Results:

    • Plasma acetate turnover and concentration positively correlated with each other and negatively with age.
    • Younger subjects (22-28 yr) showed higher acetate turnover and oxidation rates than older subjects (40-57 yr).
    • Acetate metabolism in cancer patients was comparable to healthy controls; the gastrointestinal tract was identified as a site of acetate production.

    Conclusions:

    • Age significantly influences plasma acetate turnover and oxidation, with younger individuals exhibiting higher rates.
    • Acetate metabolism appears largely preserved in cancer patients relative to their age-matched healthy counterparts.
    • Tissue acetate handling, particularly by the gut, liver, and leg, is influenced by arterial acetate concentration.