Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function in beta-thalassaemia major.

M A Hussain, R A Hutton, O Pavlidou

    Journal of Clinical Pathology
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein.

    FEBS letters·1998
    Same author

    New approaches to the management of hepatitis and endocrine disorders in Cooley's anemia.

    Annals of the New York Academy of Sciences·1998
    Same author

    Iron chelation therapy: the need for orally active drugs.

    The Journal of laboratory and clinical medicine·1998
    Same author

    Herbimycin A accelerates the induction of apoptosis following etoposide treatment or gamma-irradiation of bcr/abl-positive leukaemia cells.

    Oncogene·1998
    Same author

    Lack of clonal BCRA2 gene deletion on chromosome 13 in chronic lymphocytic leukaemia: an update of recent scientific reports.

    British journal of haematology·1998
    Same author

    Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients.

    Blood·1998
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    Same journal

    Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

    Journal of clinical pathology·2026
    Same journal

    MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

    Journal of clinical pathology·2026
    Same journal

    Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

    Journal of clinical pathology·2026
    Same journal

    Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

    Journal of clinical pathology·2026
    See all related articles

    Patients with beta-thalassaemia major and iron overload often exhibit abnormal platelet aggregation. This platelet dysfunction may not correlate with disease severity or lead to significant bleeding, potentially due to in vitro artifacts.

    Area of Science:

    • Hematology
    • Thrombosis
    • Red blood cell disorders

    Background:

    • Beta-thalassaemia major is a severe inherited blood disorder.
    • Transfusional iron overload is a common complication in beta-thalassaemia major management.
    • Platelet dysfunction can occur in various hematological conditions.

    Purpose of the Study:

    • To investigate platelet aggregation in patients with beta-thalassaemia major and transfusional iron overload.
    • To determine if platelet aggregation defects correlate with clinical parameters or iron overload severity.

    Main Methods:

    • Assessed platelet aggregation in 18 patients with beta-thalassaemia major.
    • Correlated aggregation results with liver fibrosis, liver function tests, splenectomy status, iron overload degree, hematocrit, platelet count, vitamin E, and leucocyte ascorbate levels.

    Related Experiment Videos

  • Evaluated bleeding times and clinical hemorrhage incidence.

    • Main Results:

    • Abnormal platelet aggregation was observed in 44% of patients.
    • No correlation was found between aggregation defects and clinical or laboratory parameters.
    • Only 3 patients had prolonged bleeding times, and only 1 experienced significant hemorrhage.

    Conclusions:

    • A subset of beta-thalassaemia major patients with iron overload display abnormal platelet function.
    • The clinical significance of this in vitro platelet abnormality may be limited.
    • Potential in vitro artifacts during sample processing could contribute to observed aggregation defects.