Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental allergic neuritis: a new experimental approach.

W A Sheremata, P O Behan

    Journal of Neurology, Neurosurgery, and Psychiatry
    |February 1, 1973
    PubMed
    Summary

    Experimental allergic neuritis (EAN) in guinea pigs shows hypersensitivity to both central and peripheral nervous system antigens, suggesting a shared antigen. This research clarifies EAN pathogenesis and antigen involvement.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Abstracts of the proceedings of the 20th annual meeting of the irish neurological association held on 25th-26th may, 1984.

    Irish journal of medical science·2016
    Same author

    Abnormalities of carnitine metabolism in chronic fatigue syndrome.

    European journal of neurology·2013
    Same author

    Myasthenic crisis.

    QJM : monthly journal of the Association of Physicians·2008
    Same author

    Treatment of multiple sclerosis: beyond the NICE guidelines.

    QJM : monthly journal of the Association of Physicians·2005
    Same author

    In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.

    Prostaglandins, leukotrienes, and essential fatty acids·2004
    Same author

    Randomized multicenter trial of natalizumab in acute MS relapses: clinical and MRI effects.

    Neurology·2004

    Area of Science:

    • Neuroimmunology
    • Immunopathology
    • Cellular Hypersensitivity

    Background:

    • Experimental Allergic Neuritis (EAN) is an autoimmune disease affecting the peripheral nervous system.
    • Understanding the antigenic targets in EAN is crucial for elucidating its pathogenesis.
    • Cellular hypersensitivity plays a role in delayed-type hypersensitivity reactions.

    Purpose of the Study:

    • To investigate hypersensitivity to peripheral and central nervous system antigens in the guinea-pig model of EAN.
    • To compare hypersensitivity profiles in EAN with experimental allergic encephalitis (EAE).
    • To explore the potential for shared antigenic components between central and peripheral nervous system tissues.

    Main Methods:

    • Macrophage migration inhibition assay was used as a measure of cellular hypersensitivity.
    • Guinea pigs were induced with EAN and EAE.
    • Immune responses were assessed against central and peripheral nervous system antigens.

    Main Results:

    • EAN model demonstrated hypersensitivity to both central and peripheral nervous system antigens.
    • Experimental allergic encephalitis model showed hypersensitivity exclusively to the central nervous system antigen.
    • These findings suggest a common antigenic determinant shared by central and peripheral nervous system tissues.

    Conclusions:

    • Hypersensitivity to nervous system antigens is implicated in the pathogenesis of EAN.
    • Evidence supports a shared antigenic component between peripheral and central nervous system antigens.
    • A preliminary hypothesis regarding the antigenic basis of EAN is proposed.

    Related Experiment Videos