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Why should dialysis benefit schizophrenia?

I M Cohen, S C Scheiber, H Yamamura

The Journal of Nervous and Mental Disease

|August 1, 1979

Summary

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Dialysis may treat schizophrenia by removing a unique toxin. Research should focus on small, nonprotein compounds that artificial kidneys filter but human kidneys do not, potentially identifying a "schizophrenic toxin".

Area of Science:

Biochemistry
Nephrology
Psychiatry

Background:

Schizophrenia treatment remains a challenge.
Dialysis has shown potential efficacy in treating schizophrenia.
The mechanism of dialysis's effectiveness in schizophrenia is not fully understood.

Purpose of the Study:

To hypothesize the nature of a potential "schizophrenic toxin" removed by dialysis.
To guide future biochemical research into the causes of schizophrenia.

Main Methods:

Theoretical analysis of kidney and artificial kidney filtration capabilities.
Consideration of molecular weight and binding properties of potential toxins.

Main Results:

The artificial kidney removes substances the human kidney cannot, suggesting a retained abnormal compound in schizophrenia.

Related Experiment Videos

A "schizophrenic toxin" is likely a nonprotein, nonprotein-bound molecule under 500 daltons, such as an organic acid or base.

Conclusions:

The human kidney's inability to excrete a specific abnormal compound is more probable than a diseased kidney.
Future research should investigate small, dialyzable organic molecules as potential causes or markers of schizophrenia.