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Updated: Sep 21, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Abstract:
Considering a random mating population of finite size, the variance of the number of loci having a given gene frequency was derived under the assumption of a steady flux of mutations. The variance of average heterozygosity among populations was also derived under the same assumption. It was shown that these variances are proportional to the population size if the mutants are selectively neutral, and they are inversely proportional to the selection coefficient if the mutants are selectively advantageous and additive in their fitness.
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