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Macrophage migration technique using coccidioidin.

J T Sinski, G L Reed, L M Kelley

    Infection and Immunity
    |February 1, 1973
    PubMed
    Summary
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    Guinea pigs showed skin reactions after coccidioidin testing. However, their macrophages did not exhibit significant migration inhibition, suggesting a complex immune response to coccidioidin.

    Area of Science:

    • Immunology
    • Dermatology
    • Microbiology

    Background:

    • Coccidioidin is used to test for Coccidioides immitis infection.
    • Skin testing is a common method for assessing cell-mediated immunity.

    Purpose of the Study:

    • To evaluate the immune response in guinea pigs sensitized to coccidioidin.
    • To investigate both dermal hypersensitivity and macrophage migration inhibition.

    Main Methods:

    • Guinea pigs were repeatedly skin tested with merthiolated coccidioidin.
    • Intradermal injections were administered to assess skin reactions.
    • Peritoneal exudate macrophages were isolated to test for migration inhibition.

    Main Results:

    • Sensitized guinea pigs displayed erythema, edema, and induration upon intradermal injection.

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  • No statistically significant migration inhibition of macrophages was observed in these animals.

    • Conclusions:

    • Guinea pigs exhibit a dermal hypersensitivity reaction to coccidioidin.
    • The observed skin reactions do not correlate with significant macrophage migration inhibition in this model.