The respiratory action of phenyl diguanide in vagotomized rabbits

In anaesthetized rabbits phenyl diguanide not only stimulates breathing (rapid shallow breathing) by a vagal reflex from lung J-receptors, but also causes a similar response in bilateral vagotomized animals. Injection of the drug into different parts of the circulation indicates that the main non-vagal response of breathing arises from areas supplied by the vertebral arteries, presumably in the brain.