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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Updated: Jan 2, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

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Life-threatening dermatoses.

D L Cram

    California Medicine
    |February 1, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Four severe skin conditions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, present suddenly and can be fatal. Early diagnosis and treatment are crucial for patient survival and preventing lasting effects.

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    Area of Science:

    • Dermatology
    • Internal Medicine
    • Critical Care Medicine

    Background:

    • Four dermatoses (Stevens-Johnson syndrome, toxic epidermal necrolysis, Kaposi's varicelliform eruption, purpura fulminans) are characterized by abrupt onset and rapid progression.
    • These conditions pose a significant risk of mortality if not managed promptly.

    Purpose of the Study:

    • To highlight the critical importance of prompt diagnosis and appropriate therapy for life-threatening dermatoses.
    • To underscore the need for physician awareness regarding these serious conditions.

    Main Methods:

    • This is a review and synthesis of clinical knowledge regarding four severe dermatological conditions.
    • The abstract does not detail specific experimental methods but focuses on clinical presentation and management principles.

    Main Results:

    • Prompt diagnosis and proper therapy can lead to cure or prevention of sequelae in these severe dermatoses.
    • Two of the conditions are associated with drug use, and all four can be secondary to infections.

    Conclusions:

    • Physicians in all specialties must be aware of the seriousness and potential triggers (drugs, infections) of these four dermatoses.
    • Vigilance and timely intervention are key to improving outcomes for patients with these critical conditions.