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Lysozymuria and acute disorders of renal function
Journal of Clinical Pathology
|April 1, 1973
Summary
Urinary lysozyme (lysozymuria) can indicate kidney tubular dysfunction. While it appeared in various acute conditions, its diagnostic value for impaired renal function is limited, though it offers insights into kidney pathophysiology.
Area of Science:
- Nephrology
- Clinical Chemistry
- Renal Pathophysiology
Background:
- Urinary lysozyme concentration (lysozymuria) is often assumed to reflect tubular proteinuria and impaired renal tubular function.
- Acute conditions can cause transient disturbances in renal function, necessitating evaluation of markers like lysozymuria.
Purpose of the Study:
- To investigate the presence and significance of lysozymuria in various acute medical and surgical conditions.
- To assess the diagnostic utility of lysozymuria for identifying impaired renal function in acute disorders.
Main Methods:
- Estimation of urinary lysozyme concentration in patients with acute disorders, extrarenal uremia, and acute renal disease.
- Correlation of lysozymuria findings with clinical diagnoses and specific conditions.
Main Results:
- Reversible lysozymuria was observed in conditions such as hypokalemia, post-operative collapse, electrolyte depletion, severe infections, acute pyelonephritis, nephrotic syndrome, and after surgery or DC shock.
- Lysozymuria was notably absent in severe uraemic heart failure, drug poisonings (aspirin, paracetamol), severe jaundice, and acute glomerulonephritis.
Conclusions:
- Lysozymuria can occur in a range of acute conditions, suggesting potential renal involvement or tubular stress.
- The diagnostic value of lysozymuria for acute renal dysfunction is limited, but it provides valuable insights into renal pathophysiology during acute illness.