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Ureteric stricture with analgesic nephropathy.

G A MacGregor, N F Jones, M A Barraclough

    British Medical Journal
    |May 5, 1973
    PubMed
    Summary
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    Analgesic abuse can cause upper urinary tract dilation due to ureteric fibrosis, even without intraluminal obstruction. This finding suggests a link between analgesic consumption and retroperitoneal fibrosis.

    Area of Science:

    • Nephrology
    • Urology
    • Pathology

    Background:

    • Analgesic nephropathy is a known kidney disease associated with chronic pain reliever use.
    • Upper urinary tract obstruction is typically caused by intraluminal issues.

    Purpose of the Study:

    • To report three cases of upper urinary tract dilation caused by ureteric or periureteric fibrosis in patients with analgesic nephropathy.
    • To explore the association between analgesic abuse and ureteric fibrosis.
    • To investigate a potential role for analgesic abuse in retroperitoneal fibrosis.

    Main Methods:

    • Case report of three patients.
    • Clinical and pathological examination of the urinary tract.
    • Review of patient history regarding analgesic consumption.

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    Main Results:

    • Three patients with analgesic nephropathy presented with upper urinary tract dilation.
    • The dilation was attributed to ureteric or periureteric fibrosis without intraluminal obstruction.
    • A potential association between analgesic abuse and the development of retroperitoneal fibrosis was suggested.

    Conclusions:

    • Analgesic abuse can lead to upper urinary tract dilation via ureteric/periureteric fibrosis.
    • Patients with unexplained ureteric fibrosis should be evaluated for analgesic consumption.
    • Analgesic abuse may contribute to the pathogenesis of retroperitoneal fibrosis.