Epidermolysis bullosa dystrophica treated with vitamin E and oral corticosteroids

A 12-year-old boy with histologically proved epidermolysis bullosa dystrophica was treated daily with 10,000 IU of DL-alphatocopheryl acetate and prednisone 120 mg. Comparison of a control study period of seven weeks with the period during which vitamin E was given revealed no significant improvement. The same negative results were noted with the use of prednisone although the levels believed necessary to produce improvement were never attained owing to supervening infection.