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Related Experiment Videos

Choreiform movements induced by anticholinergic therapy.

R W Warne, S S Gubbay

    The Medical Journal of Australia
    |May 19, 1979
    PubMed
    Summary
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    Long-term anticholinergic drug therapy, specifically benzhexol, can cause choreiform movements in elderly patients. These involuntary movements resolved after discontinuing the medication, highlighting a potential adverse drug reaction in this population.

    Area of Science:

    • Neurology
    • Clinical Pharmacology
    • Geriatrics

    Background:

    • Anticholinergic medications are frequently prescribed for various conditions, particularly in the elderly.
    • Adverse drug reactions are a significant concern in geriatric populations due to physiological changes.
    • Benzhexol is an anticholinergic agent used historically for conditions like Parkinsonism.

    Observation:

    • A 73-year-old male patient developed involuntary, jerky movements consistent with chorea.
    • The onset of choreiform movements was associated with long-term treatment with benzhexol.
    • The patient had no prior history of movement disorders.

    Findings:

    • The choreiform movements completely resolved after the cessation of benzhexol therapy.
    • This case represents the first reported instance of benzhexol-induced chorea.

    Related Experiment Videos

  • The elderly are identified as a vulnerable group for developing drug-induced movement disorders.

    • Implications:

    • Clinicians should consider anticholinergic medications as a potential cause of new-onset chorea in elderly patients.
    • Discontinuation of offending anticholinergic agents may lead to the resolution of drug-induced chorea.
    • This finding underscores the importance of careful medication review and monitoring for adverse effects in geriatric pharmacotherapy.