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Admixture studies and the detection of selection.

J Adams, R H Ward

    Science (New York, N.Y.)
    |June 15, 1973
    PubMed
    Summary

    Admixture studies offer limited evidence for natural selection in human populations. These methods, including homogeneity testing, often yield results attributable to random genetic drift rather than adaptive evolution.

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    Area of Science:

    • Population Genetics
    • Human Evolution
    • Genomic Studies

    Background:

    • Admixture studies analyze genetic contributions from distinct ancestral populations.
    • Identifying natural selection requires robust statistical methods to differentiate from other evolutionary forces.
    • Previous admixture studies have faced challenges in providing conclusive evidence for selection.

    Purpose of the Study:

    • To evaluate the efficacy of three statistical methods in detecting natural selection using admixture data.
    • To assess evidence for natural selection in U.S. Black populations through admixture analysis.
    • To investigate the reliability of admixture studies as a tool for identifying natural selection in humans.

    Main Methods:

    • Classification of admixture estimates into distinct groups.
    • Calculation of rank correlation between admixture estimates across multiple populations.
    • Testing admixture estimates for statistical homogeneity.

    Main Results:

    • Two of five U.S. Black populations exhibited heterogeneous admixture estimates.
    • Other statistical tests for natural selection were largely non-significant.
    • Inconsistent significant findings were more suggestive of random genetic drift or biased gene frequency estimates.

    Conclusions:

    • Admixture studies provide minimal evidence for natural selection in the studied human populations.
    • Distinguishing natural selection from random genetic drift and data biases in admixture studies is challenging.
    • Admixture studies may serve best as preliminary screening tools for natural selection rather than definitive evidence.

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