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Physiological changes in ageing muscles.

M J Campbell, A J McComas, F Petito

    Journal of Neurology, Neurosurgery, and Psychiatry
    |April 1, 1973
    PubMed
    Summary
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    Physiological studies reveal age-related muscle wasting and weakness in elderly individuals due to loss of motor units. Surviving motor units show dysfunction, indicating motoneurone issues in aging.

    Area of Science:

    • Neuroscience
    • Physiology
    • Gerontology

    Background:

    • Aging is associated with physiological changes in skeletal muscles.
    • Motor unit alterations are implicated in age-related muscle decline.

    Purpose of the Study:

    • To investigate physiological changes in the extensor digitorum brevis muscle in healthy elderly subjects.
    • To determine the underlying causes of age-related muscle wasting and weakness.

    Main Methods:

    • Physiological assessment of extensor digitorum brevis muscles.
    • Analysis of motor unit number, size, and contractile properties.
    • Measurement of nerve impulse conduction velocities.

    Main Results:

    • Evidence of significant muscle wasting and weakness in elderly subjects (60-96 years).

    Related Experiment Videos

  • Muscle changes attributed to a loss of functioning motor units.
  • Surviving motor units were enlarged with slower twitches; reduced nerve impulse conduction velocities observed, particularly in distal axons.

    • Conclusions:

    • Findings suggest motoneurone dysfunction is present in old age.
    • Age-related loss of motor units contributes to muscle weakness.
    • Altered nerve conduction indicates axonal changes affecting motor function.