Chlorite-oxidized amylose as an adjuvant for interferon production

Chlorite-oxidized amylose (COAM), when given intraperitoneally to mice and to cats, increased the titer of serum interferon subsequently induced by polyinosinic.polycytidylic acid (In.Cn). Increases ranged from 6- to 100-fold. Maximal effect was observed when COAM was given 3 h prior to In.Cn. COAM given intravenously prior to Newcastle disease virus also significantly increased serum interferon titers.