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The structure of hydroxyethyl starch.

W Banks, C T Greenwood, D D Muir

    British Journal of Pharmacology
    |January 1, 1973
    PubMed
    Summary
    This summary is machine-generated.

    The current model for hydroxyethyl starch is too simple. A new, more complex model is proposed and validated, showing the simple model is incorrect for this plasma volume expander.

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    Area of Science:

    • Biochemistry
    • Polymer Chemistry

    Background:

    • Hydroxyethyl starch (HES) is widely used as a plasma volume expander.
    • The current structural model of HES is considered a simplification.

    Purpose of the Study:

    • To propose and validate a more complex structural model for hydroxyethyl starch.
    • To develop a rapid test to differentiate between proposed HES structural models.

    Main Methods:

    • Development of a novel, rapid analytical test.
    • Enzymic hydrolysis studies of hydroxyethyl starch.

    Main Results:

    • The proposed complex substitution-pattern model for HES is validated.
    • The simple structural model for HES is demonstrated to be inaccurate.

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  • Enzymic hydrolysis provides qualitative support for the complex model.
  • Conclusions:

    • The established model for hydroxyethyl starch structure is an oversimplification.
    • A complex substitution-pattern model accurately describes hydroxyethyl starch.
    • The findings necessitate a re-evaluation of HES structure and its implications.