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Related Experiment Videos

[Iodine overloads in amniotic fluids (author's transl)].

N Etling, J P Vielh

    La Nouvelle Presse Medicale
    |May 5, 1979
    PubMed
    Summary

    Iodine levels in amniotic fluid increase significantly after pregnant women receive iodinated drugs, particularly urography. While no neonatal hypothyroidism was observed, fetal risk remains a concern with iodinated drug administration during pregnancy.

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    First-month variations in total iodine content of human breast milks.

    Early human development·1986

    Area of Science:

    • Obstetrics and Gynecology
    • Endocrinology
    • Pharmacology

    Context:

    • Amniotic fluid iodine levels are critical indicators of fetal exposure.
    • Iodinated contrast agents are frequently used in medical imaging during pregnancy.
    • Iodine excess in amniotic fluid can potentially impact fetal thyroid function.

    Purpose:

    • To quantify iodine levels in amniotic fluid of high-risk pregnant women.
    • To investigate the source and magnitude of iodine load from iodinated drugs.
    • To assess the potential risk of neonatal hypothyroidism following maternal administration of iodinated drugs.

    Summary:

    • Mean total iodine levels in amniotic fluid were 7.8 ng/ml mid-pregnancy and 4.4 ng/ml late-pregnancy.
    • 14% of amniotic fluid samples from high-risk pregnancies showed iodine load, primarily from water-soluble iodinated drugs.
    • Urography led to an 80,000-fold increase in iodine levels 24 hours post-administration, with released iodide detected.

    Impact:

    • No neonatal hypothyroidism was observed in the study cohort, possibly due to rapid iodine degradation.
    • Maternal administration of iodinated drugs, even those below 300 ng/ml, poses a potential risk to the developing fetus.
    • Highlights the need for careful consideration of iodinated drug use in pregnant women due to potential fetal exposure risks.

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