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[Corticosteroid osteoporosis (author's transl)].

J L Siame, J L Sebert, B Delcambre

    La Nouvelle Presse Medicale
    |May 5, 1979
    PubMed
    Summary

    Prolonged corticosteroid use can cause osteoporosis. Prevention involves careful corticosteroid prescription and ensuring adequate calcium and vitamin D intake to maintain bone health.

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    Area of Science:

    • Endocrinology
    • Bone Metabolism
    • Pharmacology

    Background:

    • Osteoporosis is a frequent and severe complication of long-term corticosteroid treatment.
    • Corticosteroids impact bone health through multiple mechanisms.
    • Understanding these mechanisms is crucial for effective management.

    Purpose of the Study:

    • To review the clinical, radiological, histological, and biological features of corticosteroid-induced osteoporosis.
    • To discuss the physiopathogenic mechanisms underlying this condition.
    • To outline preventive treatment strategies.

    Main Methods:

    • Review of clinical, radiological, histological, and biological data.
    • Discussion of physiopathogenic mechanisms.
    • Synthesis of current treatment recommendations.

    Main Results:

    • Corticosteroids exert anti-anabolic effects, decreasing bone formation.
    • Secondary hyperparathyroidism results from corticosteroid-induced calcium deficiency and reduced intestinal absorption.
    • Preventive measures are essential for managing this complication.

    Conclusions:

    • Careful corticosteroid prescription, including absolute indication, minimal effective dose, and alternate day administration, is key.
    • Optimizing calcium balance through supplementation (calcium, vitamin D) is crucial for prevention.
    • A proactive approach combining judicious corticosteroid use and nutritional support can mitigate osteoporosis risk.

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