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Related Experiment Videos

Epsilon aminocaproic acid (EACA) myopathy.

R J Lane, N J McLelland, A M Martin

    Postgraduate Medical Journal
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    High doses of epsilon-aminocaproic acid can cause severe myopathy. This muscle disorder resolved after discontinuing the drug, indicating a potential drug-induced myotoxicity.

    Area of Science:

    • Neurology
    • Toxicology

    Background:

    • Epsilon-aminocaproic acid is used to treat bleeding disorders.
    • Drug-induced myopathies are a known concern with certain medications.

    Observation:

    • Two female patients presented with severe, painful proximal myopathy.
    • Symptoms developed after daily intake of 18-30g of epsilon-aminocaproic acid for 5 weeks.

    Findings:

    • Patients exhibited elevated serum aminotransferases, creatine kinase, and aldolase.
    • Electromyography and muscle biopsy revealed acute necrotizing myopathy in one patient.
    • Muscle abnormalities resolved after drug cessation.

    Implications:

    • Epsilon-aminocaproic acid may induce toxic myopathy.

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  • Clinicians should consider myotoxicity in patients on high-dose epsilon-aminocaproic acid.
  • Further investigation into drug-induced myopathy is warranted.