Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spontaneous activity in isolated bovine mesenteric lymphatics.

H J Mawhinney, I C Roddie

    The Journal of Physiology
    |March 1, 1973
    PubMed
    Summary

    Bovine lymphatic vessels exhibit spontaneous contractions, with strength correlating to pause duration. Noradrenaline and isoprenaline influence contraction frequency and amplitude via specific receptor pathways.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Peripheral vascular effects of bretylium tosylate in man.

    British journal of pharmacology and chemotherapy·2008
    Same author

    The effect of propranolol on the response of the rat isolated heart to noradrenaline.

    British journal of pharmacology and chemotherapy·2008
    Same author

    Recollections of Professor Henry Barcroft, F.R.S.

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1998
    Same author

    Retrosternal dislocation of the sternoclavicular joint.

    Journal of the Royal College of Surgeons of Edinburgh·1995
    Same author

    The effect of acute changes in blood flow on local lymph flow in the limbs of anesthetized sheep.

    Lymphology·1990
    Same author

    Lymph flow in sheep limbs during local exposure to subatmospheric pressure.

    The Journal of physiology·1989

    Area of Science:

    • Cardiovascular Physiology
    • Lymphatic System Dynamics

    Background:

    • The lymphatic system is crucial for fluid balance and immune function.
    • Understanding lymphatic vessel contractility is key to comprehending lymph transport.

    Purpose of the Study:

    • To investigate the contractile properties of isolated bovine mesenteric lymphatic vessels.
    • To determine the effects of autonomic neurotransmitters on lymphatic contractility.

    Main Methods:

    • Measurement of longitudinal tension in isolated bovine mesenteric lymphatic vessel segments.
    • Assessment of spontaneous rhythmic contractions and responses to noradrenaline, isoprenaline, and acetylcholine.
    • Pharmacological blockade of alpha- and beta-adrenergic receptors.

    Main Results:

    • Spontaneous rhythmic contractions were observed in 17/39 vessels, with a mean frequency of approximately 2/min.
    • Contraction strength was positively correlated with the preceding pause duration.
    • Noradrenaline increased contraction frequency and decreased amplitude (alpha-receptor mediated).
    • Isoprenaline decreased contraction frequency (beta-receptor mediated).
    • Acetylcholine demonstrated minimal effect on spontaneous contractions.

    Conclusions:

    • Bovine mesenteric lymphatic vessels possess intrinsic contractile capabilities.
    • Neurotransmitters like noradrenaline and isoprenaline modulate lymphatic contractility through distinct adrenergic receptor mechanisms.
    • These findings contribute to the understanding of lymphatic system physiology and potential therapeutic targets.

    Related Experiment Videos