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Experimentally induced Cheyne-Stokes breathing.

N S Cherniack, C von Euler, I Homma

    Respiration Physiology
    |July 1, 1979
    PubMed
    Summary
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    Researchers investigated periodic breathing in anesthetized cats, finding that increasing controller gain, particularly with hypoxia, can induce it. Reducing controller gain or enhancing carbon dioxide drive stabilizes breathing.

    Area of Science:

    • Respiratory Physiology
    • Neuroscience
    • Anesthesiology

    Background:

    • Periodic breathing is a complex respiratory pattern with implications for anesthesia and critical care.
    • Understanding the control mechanisms of breathing is crucial for managing respiratory instability.

    Purpose of the Study:

    • To investigate the factors influencing the occurrence of periodic breathing in pentobarbitone-anesthetized cats.
    • To determine the role of controller gain and chemical drives (hypoxia, hypercapnia) in inducing and preventing periodic breathing.

    Main Methods:

    • Cats anesthetized with pentobarbitone were studied under spontaneous and mechanically ventilated conditions using a servo-respirator.
    • Controller gain was manipulated by adjusting respirator settings and through lung deflation.

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  • Chemical drives were altered by inducing hypoxia, hypercapnia, and by manipulating central chemosensitivity.

    • Main Results:

    • Sustained periodic breathing was induced by increasing controller gain, either via respirator settings or lung deflation.
    • Hypoxia potentiated periodic breathing, especially when central (CO2, H+) drive was diminished.
    • Reducing controller gain to zero or enhancing the (CO2, H+) drive abolished periodic breathing.

    Conclusions:

    • Increasing controller gain is a key factor in inducing periodic breathing.
    • The interplay between hypoxic and hypercapnic drives significantly influences ventilatory stability.
    • The findings support theoretical models of respiratory control oscillations and highlight the importance of (CO2, H+) drive in maintaining stable breathing.