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Related Experiment Videos

Particulate emboli retained by the Intersept (R) transfusion filter; a sem study.

R G Guidoin, J Wallace, H Mitchell

    Revue Francaise De Transfusion Et Immuno-Hematologie
    |March 1, 1979
    PubMed
    Summary

    The Intersept transfusion filter removes microaggregates and damaged cells via adsorption and mechanical retention. While safe for blood components, fresh blood may cause thrombotic material accumulation.

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    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Medical Device Technology

    Background:

    • Transfusion filters are crucial for removing harmful substances from blood products.
    • The Intersept (R) filter, developed by Johnson and Johnson, utilizes dual-action filtration.
    • Understanding its efficacy and potential limitations is vital for transfusion safety.

    Purpose of the Study:

    • To evaluate the filtration mechanisms of the Intersept (R) transfusion filter.
    • To assess the impact of the filter on blood components.
    • To identify any potential adverse effects associated with its use.

    Main Methods:

    • Filtration analysis employing both adsorption and mechanical retention principles.
    • Assessment of trapped materials, including microaggregates and cellular debris.

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  • Evaluation of blood component integrity post-filtration.

    • Main Results:

    • The Intersept (R) filter effectively traps microaggregates and damaged/injured cells.
    • Filtration process does not appear injurious to essential blood components.
    • Accumulation of thrombotic material was observed specifically with fresh blood.

    Conclusions:

    • The Intersept (R) filter offers effective removal of blood contaminants.
    • It preserves the integrity of blood components during filtration.
    • Caution is advised regarding potential thrombotic material buildup when using fresh blood.