Related Experiment Video
Updated: Aug 15, 2026

Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine
Published on: August 24, 2018
Adverse effects of pancuronium in patients with hemorrhagic shock
Abstract:
Thirty-five patients with hemorrhagic shock had surgical repair of trauma to the great vessels using a ketamine-pancuronium-nitrous oxide sequence for anesthesia. The data of the cardiovascular and respiratory changes occurring during anesthesia and the operation were tabulated and subjected to multifactorial computer analysis. Fifteen patients died during or after operation because the injury was beyond repair. Twenty survived the oepration. Profound hypotension associated with mild tachycardia occurred with surprising regularity each time incremental doses of pancuronium were administered in nearly all patients. This hypotension was not associated with the administration of any other drug or with any other parameter and strongly implicates pancuronium as the causative factor. Pancuronium should be used cautiously and administered in small increments to this type of patient if it is used as a muscle relaxant.
More Related Videos
Related Concept Videos
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Although all competitive neuromuscular blockers are designed...
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Cardiopulmonary Resuscitation IV: Pharmacological Management
Pulmonary Embolism I: Introduction
Hemorrhagic Stroke ll: Pathophysiology

