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Related Experiment Videos

A neuronal inhibition mediated electrically.

D S Faber, H Korn

    Science (New York, N.Y.)
    |February 9, 1973
    PubMed
    Summary
    This summary is machine-generated.

    The goldfish Mauthner cell

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    Area of Science:

    • Neuroscience
    • Cellular Neuroscience
    • Fish Neuroscience

    Background:

    • The Mauthner cell is a large identified neuron in fish crucial for escape behaviors.
    • Understanding Mauthner cell function is key to comprehending rapid motor responses.

    Purpose of the Study:

    • To investigate the impact of Mauthner cell activation on surrounding neurons.
    • To elucidate the mechanism and extent of Mauthner cell-induced neuronal inhibition.

    Main Methods:

    • Electrophysiological recordings in goldfish.
    • Analysis of Mauthner cell action potentials and adjacent neuronal responses.

    Main Results:

    • Mauthner cell firing caused simultaneous hyperpolarization in nearby medullary neurons up to 200 micrometers away.

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  • This hyperpolarization resulted from inward transmembrane current flow from the Mauthner cell spike.
  • The observed hyperpolarization was potent enough to block evoked spikes in adjacent neurons.

    • Conclusions:

    • Mauthner cell activation exerts a significant inhibitory influence on its local neuronal network.
    • This widespread inhibition likely plays a role in coordinating escape responses by modulating sensory processing.