Alkaline elution analysis, a new approach to the study of DNA single-strand interruptions in cells

Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

Oncogene·2007

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Oncogene·2006

Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.

Journal of medicinal chemistry·2001

How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?

Cell biochemistry and biophysics·2001

Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.

Annals of the New York Academy of Sciences·2001

Effects of c-erbB2 overexpression on the drug sensitivities of normal human mammary epithelial cells.

Journal of the National Cancer Institute·2000

Longitudinal Surgical Modeling of Early Glioblastoma Recurrence Reveals Emergence of Margin-Associated Neural Programs.

Cancer research·2026

Getting comfortable: clonal haematopoiesis creates a senescent niche for expansion.

Cancer research·2026

Aberrant Accumulation of Cyclin D1 Rewires Glutamine Metabolism and Generates a Metabolic Vulnerability in Squamous Cell Carcinoma.

Cancer research·2026

Stromal MTHFD2 Links Fibrotic Remodeling to Immune Evasion via Redox-Dependent Inflammatory Signaling in Lung Adenocarcinoma.

Cancer research·2026

Placenta-Related PEG10 Inhibits mRNA Decay to Promote Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.

Cancer research·2026

ScanTCR Enables Early Cancer Detection by Repertoire-Scale Representation of Cancer-Associated T-Cell Receptors in Peripheral Blood.

Cancer research·2026

Colorimetric analysis of Cu2+ ions using a halochromic indicator solution and an electrospun film prepared using Caesalpinia sappan L.

Analytical methods : advancing methods and applications·2026

Visualized separation of exosomes in urine using carrier ampholyte-free free-flow isoelectric focusing electrophoresis.

Journal of chromatography. A·2026

A dual-electropolymerized poly(Xylenol orange)@poly(Euchrysine) sensing interface for sustainable simultaneous electroanalysis of 5-fluorouracil and empagliflozin: density functional theory mechanistic elucidation.

Mikrochimica acta·2026

Evaluation of DNA Double-Strand Breaks in Human Sperm Following Selection by Density Gradient Centrifugation, ZyMōt, and Felix Techniques.

JBRA assisted reproduction·2026

Hydrophobic natural deep eutectic solvent-based DLLME for the green HPLC determination of paraben and alcohol preservatives in water samples.

Talanta·2026

dSEC enables ultracentrifugation-free sample preparation for single-vesicle flow cytometry of amniotic fluid.

Analytical methods : advancing methods and applications·2026

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Alkaline elution analysis, a new approach to the study of DNA single-strand interruptions in cells

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Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.

How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?

Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.

Effects of c-erbB2 overexpression on the drug sensitivities of normal human mammary epithelial cells.

Longitudinal Surgical Modeling of Early Glioblastoma Recurrence Reveals Emergence of Margin-Associated Neural Programs.

Getting comfortable: clonal haematopoiesis creates a senescent niche for expansion.

Aberrant Accumulation of Cyclin D1 Rewires Glutamine Metabolism and Generates a Metabolic Vulnerability in Squamous Cell Carcinoma.

Stromal MTHFD2 Links Fibrotic Remodeling to Immune Evasion via Redox-Dependent Inflammatory Signaling in Lung Adenocarcinoma.

Placenta-Related PEG10 Inhibits mRNA Decay to Promote Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.

ScanTCR Enables Early Cancer Detection by Repertoire-Scale Representation of Cancer-Associated T-Cell Receptors in Peripheral Blood.

Colorimetric analysis of Cu2+ ions using a halochromic indicator solution and an electrospun film prepared using Caesalpinia sappan L.

Visualized separation of exosomes in urine using carrier ampholyte-free free-flow isoelectric focusing electrophoresis.

A dual-electropolymerized poly(Xylenol orange)@poly(Euchrysine) sensing interface for sustainable simultaneous electroanalysis of 5-fluorouracil and empagliflozin: density functional theory mechanistic elucidation.

Evaluation of DNA Double-Strand Breaks in Human Sperm Following Selection by Density Gradient Centrifugation, ZyMōt, and Felix Techniques.

Hydrophobic natural deep eutectic solvent-based DLLME for the green HPLC determination of paraben and alcohol preservatives in water samples.

dSEC enables ultracentrifugation-free sample preparation for single-vesicle flow cytometry of amniotic fluid.

Related Experiment Videos

Alkaline elution analysis, a new approach to the study of DNA single-strand interruptions in cells

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