Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sotalol intoxication, two patients with concentration-effect relationships.

P J Neuvonen, E Elonen, L Tarssanen

    Acta Pharmacologica Et Toxicologica
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Does co-administration of paroxetine change oxycodone analgesia: An interaction study in chronic pain patients.

    Scandinavian journal of pain·2018
    Same author

    Cytogenetic Findings and Survival in B-cell Chronic Lymphocytic Leukemia. Second IWCCLL Compilation of Data on 662 Patients.

    Leukemia & lymphoma·2016
    Same author

    Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.

    Clinical pharmacology and therapeutics·2015
    Same author

    Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

    Clinical pharmacology and therapeutics·2014
    Same author

    Grapefruit juice inhibits the metabolic activation of clopidogrel.

    Clinical pharmacology and therapeutics·2013
    Same author

    A mechanistic, model-based approach to safety assessment in clinical development.

    CPT: pharmacometrics & systems pharmacology·2013
    Same journal

    Studies on elimination of procaine. II. Linkage of procaine and p-aminobenzoic acid to plasma proteins in dog and rabbit.

    Acta pharmacologica et toxicologica·2014
    Same journal

    The peripheral action of ether estimated on isolated nerve-muscle preparation. I. Direct and indirect stimulation.

    Acta pharmacologica et toxicologica·2014
    Same journal

    Effect of hydergin (CCK 179) and tetramon bromide (terta-ethylammonium bromide) on electrical skin resistance.

    Acta pharmacologica et toxicologica·2014
    Same journal

    An examination of the synergism in the actions of codeine and acetylsalicylic acid.

    Acta pharmacologica et toxicologica·2014
    Same journal

    A study of the qualitative differences in response to analgetic drugs.

    Acta pharmacologica et toxicologica·2014
    Same journal

    Digitalis purpurea v. Digitalis lanata; an experimental and clinical investigation.

    Acta pharmacologica et toxicologica·2014
    See all related articles

    Sotalol hydrochloride overdose can cause severe cardiac arrhythmias and prolonged QT intervals, differing from other beta-blockers. Serum concentrations correlate with QT prolongation, highlighting sotalol

    Area of Science:

    • Pharmacology
    • Cardiology
    • Toxicology

    Background:

    • Sotalol hydrochloride is a beta-blocking agent used for cardiac conditions.
    • Beta-blocker overdoses typically present with bradycardia and hypotension.

    Observation:

    • Two patients ingested massive sotalol hydrochloride overdoses (2.4g and 8.0g).
    • Observed symptoms included bradycardia, hypotension, severe cardiac tachyarrhythmias, and prolonged QT intervals.

    Findings:

    • Sotalol overdose symptoms differ from other beta-blockers, notably severe tachyarrhythmias and prolonged QT.
    • Serum sotalol concentrations declined with a 13-15 hour half-life.
    • A strong correlation was found between serum sotalol levels and QT interval prolongation.

    Related Experiment Videos

    Implications:

    • Sotalol's unique effects on cardiac action potentials likely explain distinct intoxication profiles.
    • Understanding these differences is crucial for managing sotalol hydrochloride toxicity.
    • Monitoring QT interval and serum levels is vital in sotalol overdose cases.