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A scanning electron microscopy study of vascular casts from senile human brains
Acta Morphologica Neerlando-Scandinavica
|May 1, 1979
Summary
Three arterial deformities were frequently found in senile human brains using scanning electron microscopy. These vascular changes, including glomerular loops, were compared with other imaging and histological methods.
Area of Science:
- Neurology
- Vascular Biology
- Histopathology
Background:
- Cerebral small vessel disease is a common finding in aging brains.
- Understanding the structural changes in cerebral vasculature is crucial for diagnosing and managing neurological disorders.
Purpose of the Study:
- To investigate and characterize specific arterial deformities in senile human brains.
- To compare scanning electron microscopy findings of vascular casts with microangiograms and histological sections.
Main Methods:
- Scanning electron microscopy (SEM) was used to examine vascular casts from 26 human brains.
- Vascular casts were prepared from senile human brains.
- Identified arterial deformities were compared with microangiograms and histological sections.
Main Results:
- Three types of arterial deformities were frequently observed in 15 out of 26 senile brains.
- These deformities included glomerular loop formations, vascular wickerworks, and bundles.
- SEM findings were consistent with observations from microangiograms and histological analyses.
Conclusions:
- Specific arterial deformities are common in senile human brains.
- Scanning electron microscopy provides detailed insights into these vascular changes.
- Corroboration with microangiography and histology validates the SEM findings for characterizing cerebral vascular alterations.