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Related Experiment Videos

Proteins from human cerebrospinal fluid: binding with nucleic acids.

H Kubinski, M Javid

    Science (New York, N.Y.)
    |October 19, 1973
    PubMed
    Summary

    Cerebrospinal fluid (CSF) protein binding to nucleic acids like DNA and polyriboguanylic acid changes with neurological diseases. These alterations may offer new diagnostic tools for central nervous system disorders.

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    Area of Science:

    • Neuroscience
    • Biochemistry
    • Medical Diagnostics

    Background:

    • Cerebrospinal fluid (CSF) contains proteins that bind to nucleic acids.
    • Disease states can alter the levels of these protein-nucleic acid interactions in CSF.

    Purpose of the Study:

    • To investigate changes in CSF protein binding to DNA and polyriboguanylic acid in various central nervous system diseases.
    • To assess the potential diagnostic utility of these binding changes.

    Main Methods:

    • Analysis of cerebrospinal fluid (CSF) samples from patients with diagnosed neurological conditions.
    • Quantification of protein binding to DNA and polyriboguanylic acid using specific assays.

    Main Results:

    • Increased polyriboguanylic acid binding in CSF from patients with brain tumors, stroke, multiple sclerosis, and communicating hydrocephalus.
    • Decreased polyriboguanylic acid binding in obstructive hydrocephalus.
    • Elevated DNA binding in CSF from patients with hydrocephalus, epilepsy, and cortical atrophy.

    Conclusions:

    • Alterations in CSF protein binding to nucleic acids are associated with specific neurological diseases.
    • This protein-nucleic acid binding technique shows promise for diagnosing central nervous system disorders.

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