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Bone loss in primary hyperparathyroidism.

C I Gryfe

    Canadian Medical Association Journal
    |September 15, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Bone involvement, characterized by excessive cortical thinning, is very common in hyperparathyroidism. This condition affects both men and women, with incidence and severity not influenced by age or sex.

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    Area of Science:

    • Endocrinology
    • Bone Metabolism
    • Radiology

    Background:

    • Hyperparathyroidism is a condition that can affect bone health.
    • Cortical bone thinning is a potential manifestation of endocrine disorders.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of cortical bone thinning in hyperparathyroidism.
    • To determine the influence of sex and age on bone involvement in hyperparathyroidism.

    Main Methods:

    • X-ray images of the second metacarpals from 153 hyperparathyroid subjects were analyzed.
    • A cortical bone index was derived and compared to normal standards and age-matched groups.

    Main Results:

    • Cortical bone index was below normal in a majority of hyperparathyroid subjects (82.2% of women, 86.4% of men).

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  • Significant differences in cortical index were observed between hyperparathyroid and normal subjects across all age groups and sexes.
  • The severity of cortical thinning did not significantly differ between younger and older female hyperparathyroid subjects.

    • Conclusions:

    • Excessive cortical thinning is a highly prevalent finding in hyperparathyroidism.
    • Sex and age do not appear to significantly influence the incidence or severity of bone involvement in hyperparathyroidism.