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Dopaminergic terminals in the rat cortex.

A M Thierry, G Blanc, A Sobel

    Science (New York, N.Y.)
    |November 2, 1973
    PubMed
    Summary
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    Researchers destroyed noradrenergic pathways in rats, abolishing norepinephrine synthesis. However, dopamine synthesis remained normal, suggesting independent dopaminergic pathways in the rat cortex.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Neuropharmacology

    Background:

    • Ascending noradrenergic pathways are crucial for norepinephrine synthesis in the rat cortex.
    • The precise relationship between noradrenergic and dopaminergic terminals in the cortex is not fully understood.

    Purpose of the Study:

    • To investigate the biochemical evidence for independent dopaminergic terminals in the rat cortex.
    • To determine if norepinephrine synthesis is solely dependent on ascending noradrenergic pathways.

    Main Methods:

    • Bilateral microinjections of 6-hydroxydopamine were used to destroy ascending noradrenergic pathways in rats.
    • In vitro synthesis of [(3)H]norepinephrine and [(3)H]dopamine from L-[(3)H]tyrosine was measured in cortical slices and synaptosomes.

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    Main Results:

    • Destruction of noradrenergic pathways completely abolished in vitro norepinephrine synthesis in cortical preparations.
    • Normal in vitro dopamine synthesis was observed in cortical preparations from lesioned animals.
    • These findings indicate the presence of dopaminergic terminals independent of noradrenergic terminals.

    Conclusions:

    • The rat cortex contains dopaminergic terminals that function independently of noradrenergic pathways.
    • This study provides the first biochemical evidence supporting the existence of distinct dopaminergic and noradrenergic terminal systems in the rat cortex.