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Intermittent Cushing's disease.

F Bochner, C J Burke, H M Lloyd

The American Journal of Medicine

|September 1, 1979

Summary

This summary is machine-generated.

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This case study details a woman with intermittent Cushing's disease, a condition causing hormonal imbalance and psychiatric symptoms. Treatment involved bilateral adrenalectomy, leading to full recovery from psychosis and disease.

Area of Science:

Endocrinology
Psychiatry
Neuroendocrinology

Background:

Cushing's disease is a rare endocrine disorder caused by excess cortisol production, often linked to pituitary tumors.
Intermittent or cyclical Cushing's disease presents diagnostic challenges due to fluctuating hormone levels.

Observation:

A young woman experienced recurrent episodes of depression, acne, amenorrhea, hirsutism, and moon facies over four years.
Symptoms spontaneously resolved for 2-3 months during initial relapses.
Biochemical tests confirmed pituitary-dependent adrenocortical overactivity during the last two episodes.

Findings:

The patient's symptoms were consistent with intermittent Cushing's disease.
Plasma ACTH levels indicated a pituitary source for the excess cortisol production.

Related Experiment Videos

A severe depressive psychosis marked the fifth relapse, requiring intervention.

Implications:

This case highlights the importance of recognizing intermittent Cushing's disease, especially when psychiatric symptoms are prominent.
Bilateral adrenalectomy can be an effective treatment for severe, refractory Cushing's disease with psychosis.
Early diagnosis and management are crucial for preventing severe complications.