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Related Experiment Videos

Serial relaxin concentrations in human pregnancy.

J Quagliarello, N Szlachter, B G Steinetz

    American Journal of Obstetrics and Gynecology
    |September 1, 1979
    PubMed
    Summary

    Serum relaxin levels in pregnant women show a first-trimester rise and second-trimester fall, stabilizing thereafter. This confirms the corpus luteum

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    Area of Science:

    • Reproductive endocrinology
    • Maternal-fetal medicine
    • Hormone physiology

    Background:

    • Relaxin is a peptide hormone crucial for pregnancy.
    • In women, relaxin is exclusively produced by the corpus luteum.
    • Understanding relaxin dynamics is key to assessing luteal function during gestation.

    Purpose of the Study:

    • To measure serial serum relaxin concentrations throughout human pregnancy.
    • To evaluate relaxin as an indicator of corpus luteum activity during gestation.

    Main Methods:

    • Utilized a heterologous porcine radioimmunoassay for relaxin quantification.
    • Monitored serum relaxin levels in three women from early pregnancy through labor.

    Main Results:

    • Observed an initial elevation in the first trimester.
    • Documented a subsequent decline in the second trimester.
    • Found stable relaxin levels in the second and third trimesters and during labor.

    Conclusions:

    • The observed pattern confirms sustained corpus luteum function throughout pregnancy.
    • Serum relaxin levels serve as a valuable index for monitoring luteal function during gestation.

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