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Changes in 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D during pregnancy
American Journal of Obstetrics and Gynecology
|September 15, 1979
Summary
Pregnancy alters vitamin D metabolism, decreasing 25-hydroxyvitamin D (25OHD) and 24,25-dihydroxyvitamin D (24,25(OH)2D) levels. These changes suggest altered vitamin D pathways to support fetal calcium needs during gestation.
Area of Science:
- Endocrinology
- Nutritional Science
- Obstetrics
Background:
- Calcium homeostasis is critical during pregnancy.
- Vitamin D metabolites play a key role in calcium regulation.
- Gestational changes may impact vitamin D metabolism.
Purpose of the Study:
- To assess hormonal regulation of calcium homeostasis during pregnancy.
- To investigate changes in vitamin D metabolites throughout gestation.
Main Methods:
- Cross-sectional study of 94 pregnant women.
- Measurement of serum 25-hydroxyvitamin D (25OHD) and 24,25-dihydroxyvitamin D (24,25(OH)2D).
- Gestation divided into four 10-week quarters.
Main Results:
- 25OHD levels decreased significantly by the second trimester.
- 24,25(OH)2D levels decreased in the fourth quarter of pregnancy.
- Mean 24,25(OH)2D was approximately half of control values at term.
Conclusions:
- Vitamin D metabolic pathways are altered during gestation.
- Decreased 24-hydroxylation and potentially increased 1,25-dihydroxyvitamin D production are suggested.
- Changes may support increased maternal-to-fetal calcium transport.