Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Qualitative and quantitative morphological changes in subcellular fractions from mouse cerebral cortex during

W E Grove, T C Johnson, P Kelly

    The Journal of Cell Biology
    |September 1, 1973
    PubMed
    Summary

    This study reveals how synaptosomal material distribution changes during mouse brain development. Quantitative analysis of subcellular fractions shows altered synaptosome distribution and growth cone presence as neural maturation progresses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A clinical audit of MMR vaccination in the under-25s in the Defence Forces Ireland.

    Irish medical journal·2025
    Same author

    Current Practice and Outcomes of Patients Undergoing Surgical Resection for Renal Cell Metastases to the Pancreas in Northern Ireland.

    The Ulster medical journal·2024
    Same author

    Gastric Malignancy Survival in Zambia, Southern Africa: A Two Year Follow up Study.

    Medical journal of Zambia·2023
    Same author

    Estimated number of symptomatic Lyme borreliosis cases in Germany in 2021 after adjusting for under-ascertainment.

    Public health·2023
    Same author

    Correction to: Knowledge and Attitudes of Two Latino Groups About Alzheimer Disease: A Qualitative Study.

    Journal of cross-cultural gerontology·2023
    Same author

    Radium-223 in the Treatment of Metastatic Castrate-Resistant Prostate Cancer.

    Irish medical journal·2022

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Cell Biology

    Background:

    • Understanding neural development requires characterizing subcellular changes.
    • Synaptosomes are crucial for neuronal communication and their distribution evolves during maturation.

    Purpose of the Study:

    • To quantitatively assess synaptosomal material distribution during postnatal mouse cerebral cortex development.
    • To qualitatively describe maturation-dependent changes in subcellular fractions.
    • To investigate the relationship between neural maturation and growth cone distribution.

    Main Methods:

    • Preparation of subcellular fractions using discontinuous Ficoll-sucrose gradients.
    • Quantitative and qualitative examination of fractions via electron microscopy.

    Related Experiment Videos

  • Determination of synaptosomal material by volume percentage from electron micrographs.

    • Main Results:

    • Synaptosomal material distribution was quantitatively altered during postnatal neural development.
    • Qualitative, maturation-dependent changes in subcellular fractions were observed.
    • The proportion and distribution of growth cone-like structures were characterized in relation to neural maturation.

    Conclusions:

    • Synaptosome distribution and characteristics change significantly during neural development.
    • Electron microscopy and gradient fractionation provide accurate insights into subcellular particle dynamics.
    • Growth cone dynamics are linked to the overall process of neural maturation.