Jove
Visualize
Contact Us

Related Experiment Videos

A new method for treating "headaches".

D Sherwin

    The American Journal of Psychiatry
    |September 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    This study explored treating chronic headaches with perphenazine and amitriptyline. The combination therapy showed promising results, with 10 out of 14 patients experiencing relief at long-term follow-up.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An analysis of soil arsenic records of decision.

    Environmental science & technology·2001
    Same author

    [The face of the patient].

    Meditsinskaia sestra·1990
    Same author

    Faces of pain.

    Advancing clinical care : official journal of NOAADN·1989
    Same author

    Delirium tremens in a nine-year-old child.

    The American journal of psychiatry·1975
    Same journal

    Global Prevalence of Obsessive-Compulsive and Related Disorders: A Systematic Review and Modeling Study.

    The American journal of psychiatry·2026
    Same journal

    Treatment Patterns and Barriers to Care Among U.S. Adults With Co-Occurring Substance Use Disorder and Mental Illness.

    The American journal of psychiatry·2026
    Same journal

    Implantable Neuromodulation Devices in Psychiatry: Human Fidelity and Implementation Challenges.

    The American journal of psychiatry·2026
    Same journal

    Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: President-Elect Address.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: CEO and Medical Director's Address.

    The American journal of psychiatry·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Chronic headaches pose a significant challenge in clinical practice.
    • Many patients with persistent headaches do not respond to conventional treatments.

    Purpose of the Study:

    • To investigate the efficacy of a combination therapy for intractable chronic headaches.
    • To assess the long-term effectiveness of perphenazine and amitriptyline in headache management.

    Main Methods:

    • A 10-week study involving 14 patients with long-standing, treatment-resistant headaches.
    • Patients received variable doses of perphenazine and amitriptyline with suggestive therapeutic intent.

    Main Results:

    • The combined treatment regimen was successful in 10 out of the 14 participating patients.

    Related Experiment Videos

  • Positive outcomes were sustained at both 6-month and 3-year follow-up intervals.

    • Conclusions:

    • Perphenazine and amitriptyline combination therapy may offer a viable treatment option for chronic, refractory headaches.
    • Further research is warranted to confirm these findings and elucidate the underlying mechanisms.