Aberration of porphyrin metabolism in iron-deficient anaemic rats
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Published on: July 9, 2015
The Biochemical Journal
|July 1, 1973
Abstract:
Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.

