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Related Experiment Video

Updated: Jul 12, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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Small intestinal permeability in animals and man.

C A Loehry, J Kingham, J Baker

    Gut
    |September 1, 1973
    PubMed
    Summary

    Intestinal permeability decreases with increasing molecular size in humans. In rabbits, permeability declines progressively from the duodenum to the ileum for all tested substances.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Pharmacokinetics

    Background:

    • Intestinal permeability is crucial for nutrient absorption and drug delivery.
    • Understanding intestinal permeability is essential for diagnosing and treating gastrointestinal disorders.

    Purpose of the Study:

    • To investigate the relationship between molecular size and intestinal permeability in humans.
    • To examine regional differences in intestinal permeability along the small intestine in rabbits.

    Main Methods:

    • Measured plasma-to-intestinal lumen clearance of various molecular weight compounds in humans.
    • Assessed blood-to-lumen clearance of different molecular size substances across the rabbit small intestine.

    Main Results:

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  • Human studies showed a direct correlation between intestinal loss and plasma concentration.
  • Human studies demonstrated an inverse relationship between clearance and molecular size.
  • Rabbit studies revealed a progressive decrease in permeability from duodenum to ileum for all tested substances.

    • Conclusions:

    • Intestinal permeability is inversely related to molecular size in humans.
    • Regional variations in intestinal permeability exist along the rabbit small intestine, decreasing distally.