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Liver damage after liver hilus dearterialization in dogs
Annales Chirurgiae Et Gynaecologiae
|January 1, 1979
Summary
Liver dearterialization in dogs caused mild, reversible cell damage, indicated by increased serum enzymes like s-OCT and s-GDH. Cholecystectomy did not alter these liver enzyme changes but increased mortality.
Area of Science:
- Veterinary Surgery
- Hepatology
- Canine Models
Background:
- Liver hilus dearterialization is a surgical procedure with potential complications.
- Understanding the impact of dearterialization on liver function is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the effects of liver hilus dearterialization, with and without cholecystectomy, on liver enzymes and function in harrier dogs.
- To assess the necessity of adequate control groups in dearterialization studies.
Main Methods:
- Twenty-one harrier dogs underwent liver hilus dearterialization (7 with, 14 without cholecystectomy).
- Six sham-operated dogs served as controls.
- Serum enzyme activities (s-OCT, s-GDH, s-ALAT, s-ASAT, s-ALP) and liver oxygen consumption were measured.
Main Results:
- Serum enzyme activities (s-OCT, s-GDH, s-ALAT, s-ALP) significantly increased post-dearterialization, normalizing within a week.
- s-ASAT increased similarly in both dearterialized and sham-operated groups.
- Mortality was higher in the cholecystectomy group; liver oxygen consumption remained unchanged.
Conclusions:
- Liver dearterialization causes mild, reversible mitochondrial and cell membrane damage.
- Cholecystectomy increases mortality without affecting liver enzyme changes.
- Adequate controls are essential when studying dearterialization effects on the liver.