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Related Experiment Videos

Screening for abnormal haemoglobins: a pilot study.

J Stuart, F C Schwartz, A J Little

    British Medical Journal
    |November 3, 1973
    PubMed
    Summary
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    Screening immigrant schoolchildren for abnormal haemoglobins detected issues in 8.4%. This led to establishing a specialized clinic and highlighted the need for further studies before widespread UK implementation.

    Area of Science:

    • Medical Science
    • Public Health
    • Genetics

    Background:

    • Screening for abnormal haemoglobins in immigrant schoolchildren was piloted.
    • High detection rates necessitated the establishment of a dedicated haemoglobinopathy outpatient clinic.
    • The clinic also served to evaluate family screening protocols.

    Purpose of the Study:

    • To assess the implications of screening immigrant schoolchildren for abnormal haemoglobins.
    • To establish normal haemoglobin ranges for adequately nourished immigrant children.
    • To determine the effectiveness of investigating family members after an initial detection.

    Main Methods:

    • Capillary blood haemoglobin electrophoresis was used for screening 6,835 children.
    • A haemoglobinopathy outpatient clinic was established to manage workload and conduct family investigations.

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  • Normal haemoglobin ranges were determined using data from healthy siblings.

    • Main Results:

    • Abnormal haemoglobins were detected in 8.4% of screened children.
    • The established clinic managed a significant patient workload.
    • Using defined normal ranges, 10.3% of 280 children were identified as anaemic.

    Conclusions:

    • Population screening for abnormal haemoglobins is beneficial.
    • Further pilot studies are essential for patient education, genetic counselling, and healthcare logistics.
    • Wider implementation in the UK requires addressing organizational and follow-up care aspects.