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Susceptibility of Campylobacter fetus subsp. jejuni to twenty antimicrobiol agents
Abstract:
One hundred recent clinical isolates of Campylobacter fetus subsp. jejuni were tested by an agar dilution technique for susceptibility to each of 20 antimicrobial agents. Doxycycline and gentamicin were the most active of the drugs examined, inhibiting all strains at concentrations achievable in serum. Although the median minimal inhibitory concentration of erythromycin was low, 8% of the isolates were highly resistant. All isolates of Campylobacter fetus subsp. jejuni were relatively resistant to the beta-lactam antibiotics. Some strains were highly resistant to metronidazole and tinidazole.
Insights
This study assessed antimicrobial susceptibility in Campylobacter fetus subsp. jejuni. Doxycycline and gentamicin showed the best activity, while resistance to beta-lactams, metronidazole, and tinidazole was observed in some strains.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Campylobacter fetus subsp. jejuni is a significant cause of bacterial gastroenteritis.
- Understanding antimicrobial susceptibility patterns is crucial for effective treatment.
- Emerging resistance necessitates ongoing surveillance of clinical isolates.
Purpose of the Study:
- To determine the in vitro antimicrobial susceptibility of recent clinical isolates of Campylobacter fetus subsp. jejuni.
- To identify effective antimicrobial agents against this pathogen.
- To assess the prevalence of resistance to commonly used antibiotics.
Main Methods:
- Agar dilution technique was employed.
- One hundred recent clinical isolates of Campylobacter fetus subsp. jejuni were tested.
- Susceptibility to 20 different antimicrobial agents was evaluated.
Main Results:
- Doxycycline and gentamicin demonstrated potent activity, inhibiting all tested strains at achievable serum concentrations.
- Erythromycin exhibited low median minimal inhibitory concentration, but 8% of isolates displayed high resistance.
- All isolates showed relative resistance to beta-lactam antibiotics.
- Significant resistance to metronidazole and tinidazole was noted in some strains.
Conclusions:
- Doxycycline and gentamicin are promising therapeutic options for Campylobacter fetus subsp. jejuni infections.
- The emergence of erythromycin resistance warrants careful monitoring.
- Resistance to beta-lactams, metronidazole, and tinidazole highlights the need for judicious antibiotic selection.