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An electron microscopic study on the lining mucosa of developing rat vocal cords
Archives of Oto-Rhino-Laryngology
|January 1, 1979
Summary
The epithelial cells lining vocal cords transform from ciliated columnar to nonciliated squamous types. This significant change occurs between the prenatal and postnatal developmental stages in rats.
Area of Science:
- Developmental Biology
- Cell Biology
- Histology
Background:
- The vocal cord epithelium undergoes significant changes during development.
- Understanding this transformation is crucial for developmental biology and vocal cord function.
Purpose of the Study:
- To elucidate the developmental process of true vocal cord epithelial cells in rats.
- To characterize the morphological changes from fetal to postnatal stages.
Main Methods:
- Examination of rat larynges from fetal (42) and young (36) stages.
- Utilized scanning and transmission electron microscopy techniques.
Main Results:
- Prenatal vocal cords lacked squamous epithelium; lining cells were cuboidal/columnar with primary cilia.
- Postnatal development showed recognizable membranous portions with rapid regression of ciliated cells and growth of squamous cells.
Conclusions:
- Vocal cord epithelial cells transition from a ciliated columnar type to a nonciliated squamous type.
- This differentiation is a key event occurring between prenatal and postnatal development.