Related Experiment Videos
Clinical, haemodynamic, rheological, and biochemical findings in 126 patients with intermittent claudication
Insights
Increased blood viscosity significantly impacts blood flow and can cause intermittent claudication. Elevated plasma fibrinogen was the most common biochemical issue identified in patients.
Area of Science:
- Vascular Medicine
- Hematology
- Biochemistry
Background:
- Intermittent claudication is often linked to reduced blood flow.
- Blood viscosity is a critical factor in circulatory health.
Purpose of the Study:
- To analyze the role of blood viscosity in intermittent claudication.
- To identify key biochemical and clinical factors associated with the condition.
Main Methods:
- Review and analysis of clinical, hemodynamic, rheological, radiological, and biochemical data.
- Evaluation of 126 patients diagnosed with intermittent claudication.
Main Results:
- Increased blood viscosity was a significant factor in reduced blood flow, sometimes causing claudication.
- Elevated plasma fibrinogen was the most frequent biochemical abnormality.
- Red blood cell susceptibility to autoxidation correlated with clinical findings.
Conclusions:
- Blood viscosity is a key determinant in intermittent claudication.
- Plasma fibrinogen levels are important indicators in these patients.
- Further research into red blood cell properties may offer new insights.
Abstract:
Increased blood viscosity has been shown to be an important factor in reducing blood flow in a review and analysis of the history, clinical findings, and haemodynamic, rheological, radiological, and biochemical measurements in 126 patients with intermittent claudication. In some patients increased viscosity seemed to be the determining cause of claudication. A raised plasma fibrinogen was the most common single biochemical abnormality. The results of conventional serum lipid and lipoprotein estimations were abnormal in the series as a whole but did not correlate with clinical findings or flow measurements at individual patient level. There was, however, a significant correlation between some clinical findings and the susceptibility of the red cells to autoxidation.