Prognostic significance of rheological and biochemical findings in patients with intermittent claudication

Area of Science:

• Vascular Medicine
• Biochemistry
• Hematology

Background:

• Intermittent claudication is a common manifestation of peripheral artery disease.
• Predicting disease progression in untreated patients is crucial for management.
• Clinical and laboratory markers require further investigation for prognostic value.

Purpose of the Study:

• To evaluate the prognostic significance of specific clinical and laboratory findings.
• To identify predictors of progressive circulatory deterioration in intermittent claudication.

Main Methods:

• A cohort of 62 untreated intermittent claudication patients was prospectively followed.
• Detailed follow-up was conducted over one to three years.
• Blood viscosity, plasma fibrinogen, and red cell lipid autoxidation were assessed initially.

Main Results:

• A significant correlation was observed between progressive circulatory disturbance and initial blood viscosity.
• Elevated plasma fibrinogen levels were associated with disease worsening.
• Increased susceptibility of red cell lipids to autoxidation predicted poorer outcomes.

Conclusions:

• Initial blood viscosity, plasma fibrinogen, and red cell lipid autoxidation are significant prognostic indicators.
• These laboratory findings can help predict the progression of peripheral circulatory impairment in intermittent claudication.