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Cardiac denervation in diabetes.

T Wheeler, P J Watkins

    British Medical Journal
    |December 8, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic autonomic neuropathy often involves vagal denervation of the heart. Measuring beat-to-beat heart rate variation offers a simple screening method for cardiac issues in these patients.

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    Area of Science:

    • Cardiology
    • Neurology
    • Endocrinology

    Background:

    • Diabetic autonomic neuropathy is a common complication.
    • Cardiac involvement, specifically vagal denervation, is a significant concern.

    Purpose of the Study:

    • To investigate vagal denervation of the heart in diabetic autonomic neuropathy.
    • To assess the utility of heart rate variation measurement for screening.

    Main Methods:

    • Monitored beat-to-beat heart rate variation in nine diabetic patients with autonomic neuropathy and controls.
    • Utilized parasympathetic and sympathetic blockade in normal subjects to understand autonomic influence on heart rate variation.

    Main Results:

    • Diabetic patients with autonomic neuropathy exhibited significantly reduced or absent beat-to-beat heart rate variation.

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  • Normal subjects' heart rate variation was abolished by parasympathetic blockade but unaffected by sympathetic blockade.

    • Conclusions:

    • Findings suggest spontaneous vagal denervation of the heart in studied diabetic patients.
    • Beat-to-beat heart rate variation measurement is a simple and effective screening tool for cardiac involvement in autonomic neuropathy.