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Related Experiment Videos

Leukocyte function in granuloma annulare.

K J Cherney, W E Lindroos, R W Goltz

    The British Journal of Dermatology
    |July 1, 1979
    PubMed
    Summary

    Peripheral blood leukocyte function in granuloma annulare patients appears normal. Studies found no abnormalities in migration, phagocytosis, or lymphocyte response, suggesting localized tissue issues may be involved.

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    Area of Science:

    • Immunology
    • Dermatology
    • Cell Biology

    Background:

    • Granuloma annulare is a benign inflammatory skin condition.
    • The role of leukocyte function in granuloma annulare pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate in vitro functional abnormalities of peripheral blood leukocytes in patients with granuloma annulare.

    Main Methods:

    • Assessed random migration and chemotaxis of polymorphonuclear leukocytes and monocytes.
    • Evaluated phagocytosis and oxidative burst (chemiluminescence) of leukocytes.
    • Measured lymphocyte uridine incorporation with and without phytohaemagglutinin stimulation.

    Main Results:

    • Leukocyte migration, phagocytosis, and oxidative burst were normal in patients compared to controls.
    • Plasma from patients did not affect normal leukocyte locomotion.
    • Lymphocyte responses to phytohaemagglutinin were unimpaired.

    Conclusions:

    • Peripheral blood leukocyte function in granuloma annulare patients is generally normal.
    • Functional abnormalities, if present, may be confined to leukocytes within affected tissue.

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